تحضير وتشخيص معقدات بعض العناصر الفلزية مع ليكاندي قاعدة شف وآزو - قاعدة شف جديدين ودراسة التثبيط الحيوي لمعقدات الذهب الثلاثي
Preparation and Characterization of Some Metal Elements Complexes with Two New Schiff Base and Azo-Schiff Base Ligands and Study the Biological Inhibition for Au(III) Complexes
- الباحث
- بان مهدي صالح
- المشرف
- منى عباس هادي
- الجامعة
- جامعة الكوفة
- الكلية / القسم
- التربية للبنات / الكيمياء
- الشهادة
- ماجستير
- السنة
- 2022
- لغة الرسالة
- انكليزي
- الكلمات المفتاحية
- Schiff base;Azo-Schiff base;Metal complexes;Biological inhibition
Abstract
The study included the preparation of two new organic ligands, the first ligand of Schiff base type (HL1), which includes in its composition two Azomethane groups. HL1=3-((4-Chlorobenzylidene)amino)-4-(((E)-(3-hydroxy-5- (hydroxymethyl)-2Methylpuridin-4-yl)methylene)amino) phenyl)(phenyl)methanone. The second type of ligand is the azo-Schiff base, which includes the azo-bridge group and the azomethine group. L2=8-((Z)-(2-((E)-1-((4-hydroxy-3-methylphenyl)imino)ethyl) Phenyl)Diazenyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione. The Schiff base ligand (HL1) was prepared in two steps, the first stage included condensation of pyridoxal hydrochloride with 3,4- diamino benzophenone, and the second stage included condensation of the resulting compound from the first stage with p-chloro benzaldehyde. the second type of ligand azo - Schiff base (L2), it was prepared in two stages. The first stage included the preparation of the azo compound resulting from the coupling of the diazonium salt of 2-amino aceto phenone with theophylline compound, then followed by condensation of the azo compound prepared above with 2-hydroxy methyl aniline. Different analytical and characterization techniques were used, including (Mass, 1H-NMR, FT-IR, UV-Visible spectroscopy, and micro- analysis of the elements (C.H.N.S) in the investigation of the prepared ligands. A series of solid metal complexes of the two prepared ligands with metal ions Co(II),Ni (II), Cu(II), Zn(II), Cd(II) and Au (III) were prepared.and all complexes were characterized by techniques Above, excluding the Mass and the 1HNMR spectroscopy of some prepared solid Metal complexes and the use of flame atomic absorption spectroscopy to determine the percentages of metal ions in the prepared complexes also studied the magnetic susceptibility and molar conductivity sensitivity of the metal complexes dissolved in DMSO at 110-3 M concentration laboratory temperature. According to above studies, it was suggested that the geometries shapes of the complexes prepared in this study were octahedral geometries, with the except for the complexes of Au (III) , which took the square planer shape. In the final stage of the study, the biological and toxicological examinations for complexes Au(III) on cancer cells and their comparison with normal cells naturally included the extent to which the possibility of using these compounds in drug treatment manner, as the effect of the complexes [Au(L1)Cl]Cl.H2O and [Au(L2)Cl]Cl2.H2O was studied. on breast cancer cells (MCF-7), and these compounds proved highly efficient in inhibiting cancer cells, while their effect was safe with normal cells. Thus, these complexes can be considered as new drug treatment preparations with high efficiency and selectivity for the mentioned type of cancer.
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