تحضير وتشخيص معقدات جديدة لعناصر انتقالية وغير انتقالية مع ليكاندات حلقية غير متجانسة مشتقة من الإيميدازول وتقييم فعاليتها البكتيرية

الباحث

رؤى رأفت عبد الجبار

المشرف

فرح طارق سعيد

الجامعة

جامعة الموصل

الكلية / القسم

كلية العلوم / قسم الكيمياء

الشهادة

ماجستير

السنة

2024

لغة الرسالة

عربي

الكلمات المفتاحية

المعقدات الفلزية ; الإيميدازول ; الليكاندات الحلقية ; الفعالية البكتيرية

The research in this thesis includes the preparation and diagnosis of (30) coordination complexes, in addition to the preparation of three basic ligands. The research included four parts: The first part: The preparation of the ligand (L1) by reacting stoichiometric moles of piperonal, diketone (benzoyl) and para-phenylenediamine. L1=4-(2-(benzo-1,3-dioxol-5-yl)-4,5-diphenyl-2,5-dihydro-1H-imidazol-1- yl)aniline (C28H23N3O2) The second part: The preparation of coordination complexes for the ligand above, in molar ratios of (1:2) (1:4) for the ligand to the metal ion, and the metal salts used are Mn(II), Ni(II), Co(II), Zn(II), Cu( II), and the complexes had the following general formula [M(L1)2Cl2], [M(L1)4Cl2]. The third part: The preparation of ligandins (L3, L2) by reacting the ligand (L1) with benzoyl chloride substitutes in the presence of triethylamine as a basic catalyst to produce the following ligands: L2=N-(4-(2-(benzo-1,3-dioxol-5-yl)-4,5-diphenyl-2,5-dihydro-1H-imidazol-1- yl)phenyl)benzamide (C35H27N3O3) L3=N-(4-(2-(benzo-1,3-dioxol-5-yl)-4,5-diphenyl-2,5-dihydro-1H-imidazol-1- yl)phenyl)-3-nitrobenzamide (C35H26N4O5) The fourth part included the preparation of the coordination complexes for ligands (L3, L2) with molar ratios of (1:1) and (1:2) ligand to the metal ion, and the metal salts used are Mn(II), Ni(II), Co(II), Zn. (II),Cu(II), and the complexes had the following general formula [M(Ln)Cl2], [M(Ln)2]Cl2 where (Ln=L2 or L3) The prepared ligands and their coordination complexes were characterized by elemental analysis, molar electr ical conductivity, electronic and infrared spectra, magnetic measurements, and nuclear magnetic resonance (1H-NMR) spectroscopy Electrical conductivity measurements showed that most of the prepared complexes were non-conductive, while complexes (26-30) were found to be conductive with a molar ratio of (L:M)(2:1). The results of magnetic measurements and electronic spectra also confirmed that all coordination complexes with the general formulas [M(L1)2Cl2], [M(Ln)Cl2] and [M(L3)2]Cl2, where (Ln=L2 or L3) have quadrilateral shapes. surfaces, while coordination complexes with general formulas [M(L1)4Cl2] and [M(L2)2]Cl2 have octahedral shapes. Density Functional Theory was used to perform theoretical calculations for the prepared ligands and complexes, and calculate some physical functions, including hardness, chemistry potential, electronic affinity index, and calculate the HOMO and LUMO energies to reach knowledge of the stability of the prepared complexes and their electrophilic behavior. The biological effectiveness of the ligands and most of the prepared complexes was also studied, and this study showed that the ligands and some of the complexes have moderate and good power to inhibit the growth of three types of bacteria, which are: (Bacillus Subtilis , Klebseiella pneumonia and Staphylococcus -aureus).

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الاسم

رقم الهاتف

البريد الإلكتروني

الغرض من الطلب (اختياري)

إرسال الطلب